I have five SEPM 12.1.4013.4013 servers and about 25,000 clients. One of the five SEPM servers is failing to provide updates to clients. Those clients are not able to download updates from the faulty SEPM server. Specifically, the URLs availble for upsdate downloads are not working from that SEPM server. For example, in a web browser, I can't download the .zip file from the faulty SEPM server (the .zip file never appears, but no error is seen), but the same URL works fine if you substitute in the other SEPM server names, and the .zip file is able to be downloaded and saved OK.
Example:
http://SEPM05:8014/content/{5A7367E1-D1F6-43b5-BD94-4AFFA896D724}/151028037/Full.zip
After several days, clients seem to give up and switch to another SEPM server.
Any ideas on a fix or further troubleshooting would be helpful. Thanks!