Enabling Multiple locations for a group in policy might cause performance issue

Hi All,

Does Enabling Multiple locations for a group in SEPM in policy might cause performance issue or not ?

Let say I have a group named "ABC"& there are 5000 clients in that group. And, if  I enable/added 4 locations in "Manage Locations" under Policies then would it impact on the performance of end user or at SEPM? What if I use only one location with respect to performance?

Thanks....