I do not need a solution (just sharing information)
I have updated my Macbook Pro to 10.11.4 when the Beta was available. After that, I noticed that for SEP, whether operating as a Managed Endpoint or Unmanaged, Virus and Spyware protection cannot be enabled (via Policy for managed, or manually for unmanaged).
The only means to work around this is to disable rootless in OS X.
I completely understand I'm working with Beta software - I'm posting this in case it helps others, and in case Symantec see it and take note of an issue with 10.11.4 (at least at present).
I'll update my own thread if subsequent betas correct the problem.
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