What are others doing for User Profile Exclusions

We need an exclusion for an application folder that resides under the logged on users profile.  C:\Users\<username>\AppData\....

This is a requirement from the application release notes.  It seems that SEP only has the USER_PROFILE variable available which by their definition is "File system folders that correspond to all the users.  So this would be c:\documents and Settings\All Users for win7 and C:\programdata\ for win 10.

I am wondering what others are doing for exceptions required by an application that SEP does not support with an available variable?  Is there a way to script the exception after the user has logged in for the first time?

Thanks.