I'm an MSP and I've encountered a disturbing trend over the last couple of weeks among 4 different workstations at 4 different client sites.
Each client is running the on-premises version of Microsoft Office 2016 Home and Business with the latest patches (automatically patched by MS). When using Microsoft Outlook 2016 with the SEP add-In enabled, Outlook will abruptly crash with a generic dialog "Outlook has encountered a problem and is restarting". After some testing, it appears that this happens when entering a folder that contains a large number ( > 600) of messages, although I'm not certain that is the trigger. Two of these clients have encountered this issue while entering their Deleted Items folders, while the other two encountered this issue with their Inboxes. In all cases, we can start Outlook in Safe Mode and disable the SEP add-in, then we can access the folders that caused the crash.
All 4 workstations are running fully-patched versions of Windows 10 - 3 of the workstations are running the Anniversary Update (1609), 1 is running the Creators Update (1703).
Of the 4 workstations, 2 are running SEP 12.1.6 MP7, 1 is running SEP 12.1.6 MP8, 1 is running SEP 12.1.6 MP9. Apparently, this is an ongoing problem that the latest update has not solved.
As much as I hate to leave ANY protection disabled, it seems that disabling the SEP add-in is the ONLY way to allow these users to continue to work without issue.
I'd appreciate any feedback or suggestions.