Compatibility SEPM & SEP

Dear Support,

I plan to upgrade SEPM from version 12.1.5 (12.1 RU5) to 12.1.6 MP6. I would like ask SEPM 12.1.6 MP6 is compatible with the SEP Client as below ?

11.0.6000.550
12.1.5337.5000
12.1.6608.6300
12.1.671.4971
12.1.7004.6500

To make sure that if I upgrade the SEPM version to 12.1.6 MP6 , those SEP clients can manage by SEPM 12.1.6 MP6 and work properly (e.g. update anti-virus pattern etc).

Please kindly advise.

Thanks
Kidd