New MP4 Client Reboot Ramifications

I'm starting my 12.1.6 MP4 upgrades and have a question on reboots. I have to schedule my server reboots during a maintenance window. What are the ramifications of installing MP4 during the week and then don't reboot until the weekend maintenance window when patches are applied?

If the client is pending a reboot, will the server still be 'protected'? Will the server continue to recieve new signatures? Or is the client just 'stuck' until a reboot enables the new MP4 client?

Appreciate the help!.....